Manzanillo is a municipality and city in the Granma Province of Cuba. By population, it is the 14th largest Cuban city and the most populated one not being a provincial seat. It is a port city in the Granma Province in eastern Cuba on the Gulf of Guacanayabo, near the delta of the Cauto River. Its access is limited by the coral reefs of Cayo Perla.

Founded in 1784, Manzanillo is also home of the medical science faculty of the University of Granma.